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The risk of adverse obstetric and neonatal outcomes among women with autoimmune disease in the US Consortium on Safe Labor, 2002-2008

Annals of Epidemiology Aug 31, 2018

Williams A, et al. - Whether pregnancies complicated by Type 1 diabetes mellitus (T1DM), systemic lupus erythematosus (SLE) Crohn’s disease, multiple sclerosis (MS) or rheumatoid arthritis (RA) would have increased risk of preeclampsia, preterm birth (PTB), small for gestational age (SGA), respiratory distress syndrome (RDS), and neonatal intensive care (NICU) admission, was investigated by analyzing singleton deliveries from the Consortium on Safe Labor (2002-2008) and comparing women with autoimmune disease (T1DM: n=536; SLE: n=230; Crohn’s: n=173; MS: n=152; RA: n=134) to 180,794 women without autoimmune disease. They observed an increased risk for pregnancy complications and adverse neonatal outcomes in women with autoimmune disease. They also noted an increased risk of a range of adverse outcomes in women with autoimmune disease, particularly T1DM and SLE, and their neonates, although heterogeneity in symptomology was observed.
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