The relation between insulin-like growth factor 1 levels and risk of depression in ischemic stroke
International Journal of Geriatric Psychiatry Aug 26, 2017
Zhang W, et al. Â The present inquiry was set to assess whether lower serum levels of insulinÂlike growth factor 1 (IGFÂ1) in the acute phase of ischemic stroke are correlated with higher risk of postÂstroke depression (PSD) over a 1Âyear period. Findings revealed that low serum IGFÂ1 levels at admission were related to a high risk of developing PSD, implying that these alterations could be involved in the pathophysiology of depression symptoms in stroke patients.
Methods
- From July 1, 2014 to August 31, 2015, participants were first-ever acute ischemic stroke (AIS) patients who were hospitalized.
- The investigation also involved 120 age-matched and sex-matched healthy controls from the same geographical area.
- After that, fasting blood samples were gathered within 24 hours of admission for IGF-I measurement.
- Finally, neurological and neuropsychological evaluations were directed at a 1-year follow-up.
Results
- 225 patients were watched for a 1-year follow-up, and seventy four of these patients (32.9%, 95%CI: 26.8%-39.0%) were diagnosed with PSD.
- It was observed in the findings that the depression distribution across the IGF-1 quartiles ranged between 61.4% (first quartile) and 8.9% (fourth quartile).
- In a multivariate model utilizing the first quartiles of the IGF-1 versus quartiles 2 through 4, together with the significant clinical variables, the marker showed prognostic information, and the odds ratio (OR) for first quartile was 3.35 [95% CI, 1.88-6.79; P = 0.001].
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