Piot I, Schweyer K, Respondek G, et al. - Researchers sought to generate a scale that may assist in monitoring clinical deficits in patients with PSP across its broad phenotypes. In the Progressive Supranuclear Palsy Clinical Deficits Scale, seven clinical domains (Akinesia-rigidity, Bradyphrenia, Communication, Dysphagia, Eye movements, Finger dexterity, and Gait & balance) are thought to be covered, each scored from 0 to 3 (no, mild, moderate, or severe deficits). Further, the development of user guidelines was done to standardize its application. Easy scale utility was identified in cognitive pretesting. They scored 164 patients (70.4 ± 7.6 years; 62% males, 35% variant phenotypes). The Progressive Supranuclear Palsy Clinical Deficits Scale had a mean completion time of 4 minutes. Correlation of the Progressive Supranuclear Palsy Clinical Deficits Scale total score with existing scales (eg, Progressive Supranuclear Palsy Rating Scale: R = 0.88) was evident. They observed a good correlation of individual Progressive Supranuclear Palsy Clinical Deficits Scale items with alike constructs in existing scales. Further, acceptable internal consistency (Cronbach's alpha: 0.75), inter-rater reliability (0.96), and test-retest stability (0.99) were evident. For a two-arm, 1-year follow-up therapeutic trial to detect 50% change, the estimated sample sizes needed per arm in Progressive Supranuclear Palsy Clinical Deficits Scale progression was 65 (two-sided, two-sample t test). They suggest the Progressive Supranuclear Palsy Clinical Deficits Scale as a rapidly completed, clinimetrically sound scale for clinical care and research linking PSP.