Chen Z, et al. - Via retrospectively analyzing clinical parameters of 163 patients diagnosed with giant cell tumor (GCT) of the extremities, researchers assessed the prognostic value of the neutrophil-to-lymphocyte ratio (NLR) and the platelet-to-lymphocyte ratio (PLR) in these patients. Using receiver operating characteristic (ROC) analysis, they defined the optimal cutoff values of NLR and PLR. They defined 2.32 as the optimal cutoff value of NLR and 116.81 as the optimal cutoff value of PLR, using these values, patients were classified into high and low NLR groups and high and low PLR groups, respectively. With the high NLR and PLR, significant associations of Campanacci stage, tumor maximum diameter, alkaline phosphatase, and C-reactive protein (CRP) were evident. The independent prognostic factors for giant cell tumor of the extremities, identified in Cox multivariate regression analysis, were the Campanacci stage and NLR. These findings are suggestive of some predictive power of NLR, as a new inflammatory index, for the prognosis of patients with giant cell tumor of the extremities.