Faraji F, et al. - Researchers investigated how sex and race/ethnicity influence prevalence trends of human papillomavirus (HPV) in oropharyngeal cancer (OPC) and survival after OPC. In this cohort study, they analyzed 20,886 HPV-positive and 10,364 HPV-negative OPC patients from the United States National Cancer Database. Men (70.6%) displayed a higher prevalence of HPV-positive tumors than women (56.3%). Over time, these tumors have increased significantly at a rate of 3.5% and 3.2% per year among men and women, respectively. The highest prevalence of HPV-positive tumors was noted among whites (70.2%), followed by Hispanics (61.3%), Asians (55.8%), and blacks (46.3%). Prevalence of HPV-positive tumors increased significantly more rapidly among Blacks and Hispanics than whites (6.5% vs 5.6% vs 3.2% per year, respectively). Neither sex nor race/ethnicity was associated with survival among patients with HPV-positive OPC in HPV-positive OPC. However, significantly higher risk of death was observed for women vs men and blacks vs whites for HPV-negative OPC.