Lee CH, et al. - The potential of salivary biomarkers [interleukin (IL)-1beta (IL-1β), IL-1 receptor antagonist (IL-1ra), IL-6, IL-8, platelet-derived growth factor-BB, vascular endothelial growth factor, MMP-8, MMP-9, C-reactive protein, and lactoferrin] for predicting the sensitivity and monitoring the response to nonsurgical periodontal therapy was determined. Among the 34 participants with severe chronic periodontitis (the test group) receiving nonsurgical periodontal therapy, analysis of salivary biomarkers suggested the utility of salivary IL-1β and MMP-8 for diagnosing periodontitis and monitoring the recovery of periodontitis following nonsurgical periodontal therapy. For predicting the sensitivity to the treatment, MMP-8 and lactoferrin were shown to have utility.