Tricò D, et al. - In a multiethnic cohort of 202 obese youths with normal glucose tolerance (NGT), researchers investigated whether 1-hour plasma glucose (1hPG) can predict changes in the glucose tolerance status during an oral glucose tolerance test (OGTT). In these youths, whole-body insulin sensitivity, insulin secretion, β-cell function, and insulin clearance were evaluated by modeling plasma glucose, insulin, and C-peptide levels. In these patients, a plasma glucose concentration ≥7.4 mmol/L at 1 hour during an OGTT was correlated with a worse clinical and metabolic phenotype and could be an independent predictor of progression to prediabetes. There were no differences among the various ethnic groups in the risk of prediabetes that were associated with 1-hour hyperglycemia.