Wong A, et al. - Since intravenous acetylcysteine has historically been administered at a fixed dose and duration of 300 mg/kg over 20-21 hours to virtually all patient considered to be at any risk for hepatotoxicity following overdose of acetaminophen, investigators studied a 12-hour treatment regimen for selected low-risk patients in this study at six metropolitan emergency departments. According to findings, acetylcysteine discontinuation based on laboratory tests after 12 hours of treatment is feasible and likely safe in selected patients at very low risk of acetaminophen overdose liver injury. No patients developed hepatic injury or hepatotoxicity in this analysis.