Slade T, Newton NC, Mather M, et al. - In lowering the uptake of alcohol use, engagement in binge drinking and alcohol‐related harms over a 3‐year period, researchers performed a cluster‐randomized controlled trial to compare the long‐term universal results of the Climate Schools program, a selective preventure program, and their combined implementation with standard substance use education. Substance use prevention programs were delivered in Australian secondary schools where participants were consenting 8th grade students from 26 Australian secondary schools (n = 2,190; mean age at baseline: 13.3 years; 57.4% male). They block‐randomized schools to one of four groups: universal prevention (climate; 12 × 40‐minute lessons); selective prevention (preventure; 2 × 90‐minute sessions); combined prevention (climate and preventure; CAP); or health education as usual (control). Assessment of participants was done at baseline, post‐intervention (6–9 months post‐baseline) and at 12, 24 and 36 months post‐baseline on measures of alcohol use, knowledge and related harms. Outcomes revealed reduced alcohol consumption and alcohol problems in correlation with the Universal Climate Schools program and the selective preventure program vs standard Australian health education, when the programs were trialled individually and together over a 3‐year period.