Paramasivan S, Bassiouni A, Shiffer A, et al. - Researchers sought to characterize the sinonasal microbiome and its geographical variations in both health and disease. For this purpose, 410 individuals from across the world were assessed using 16S rRNA gene sequencing. The individuals varied highly in the sinus microbial ecology. Both healthy and chronic rhinosinusitis (CRS) cohorts had core microbiome comprising of Corynebacterium, Staphylococcus, Streptococcus, Haemophilus and Moraxella species. The majority of patients sampled seemed to have particular predominance of Corynebacterium and Staphylococcus. A statistically significant reduction in relative abundance of Corynebacterium was observed among patients suffering from CRS with nasal polyps (40.29% vs 50.43%). Although microbiome composition and diversity showed some measurable differences between some of the participating centers in this cohort, no effect of these differences on the general pattern of core organisms described was observed. Nevertheless, atypical or unusual organisms described in short‐read amplicon sequencing studies and that are not part of the core microbiome should be carefully interpreted.