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The influence of Epstein-Barr virus and Cytomegalovirus on childhood respiratory health: A population-based prospective cohort study

Clinical & Experimental Allergy Feb 13, 2020

van Meel ER, Jaddoe VWV, Reiss IKM, et al. - Researchers analyzed 3,546 children in this study nested in a population-based prospective cohort, to determine the links of Epstein-Barr virus (EBV) and Cytomegalovirus (CMV) with lung function, asthma and inhalant allergic sensitization at school age. A higher FEV1 and FEF75 related to seropositivity for EBV, but not associated with seropositivity for CMV, was revealed in unadjusted models. As demonstrated by particular combinations of viruses, seropositivity for EBV was only related to FEV1 and FEF75 in the presence of seropositivity for CMV. A raised risk of inhalant allergic sensitization was reported in relation to seropositivity for CMV in the absence of seropositivity for EBV. Essentially following adjustment for child's ethnicity, all effect estimates attenuated into non-significant. There was no link between seropositivity for EBV or CMV and asthma.
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