O'Reilly MA, et al. - Given the significant risk posed by invasive fungal infections (IFIs) to patients with hematological malignancies, researchers explored the incidence and outcome of IFI in children and young people undergoing contemporary acute lymphoblastic leukemia (ALL) therapy and to identify risk factors associated with IFI. They included 290 patients [male = 159 (55%), female = 131 (45%)] with ALL treated on the UKALL2011 protocol, a phase 3 randomized controlled trial, at Great Ormond Street Hospital (GOSH) and University College London Hospital (UCLH) between 1 January 2013 and 1 January 2017. Outcomes revealed a low incidence (8%) of IFI on the UKALL2011 protocol. Despite the low risk of infection-related mortality, mirroring the UKALL2003 study (O'Connor et al, 2014), there is the potential to compromise the timely delivery of chemotherapy.