Toh L, et al. - Among critically ill patients, researchers determined the incidence, features, results, and associations of small, short-term, point-of-care creatinine increases. Two sequential arterial blood gas measurements were taken, between which the first episode of small (> 1 μmol/L/h), short-term (3–4 hours), point-of-care creatinine increase was identified prospectively. Overall, 387 patients were included in this study, among whom 72.1% experienced an episode of small, short-term, point-of-care creatinine increase, and acute kidney injury (AKI) development in 212 (54.8%). Findings revealed a common incidence of episodes of small, short-term, point-of-care creatinine increase in critically ill patients. Such increases developed early, preceded AKI by 10 hours, and were sensitive rather than specific markers of AKI. In addition, these increases were found to be related to illness severity.