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The incidence, characteristics, and use of suspected nephrotoxic drugs in elderly patients with community-acquired acute kidney injury

Clinical Interventions in Aging Jan 09, 2021

Hu W, Lian X, Lin J, et al. - Researchers examined the incidence, clinical features, results as well as use of suspected nephrotoxic medications following community-acquired-AKI (acute kidney injury) [CA-AKI] in the elderly. From 2013 to 2016, recruitment of 36,445 patients aged over 60 years was done. They identified 2,371 patients with CA-AKI. In elderly, CA-AKI incidence was estimated to be 26.03%. Higher percentage of cardiogenic shock, multiple organ failure, transferring to intensive care unit, cardio-pulmonary resuscitation, hemodialysis, and mortality was reported in CA-AKI patients vs non-AKI patients. Overall, CA-AKI incidence was high in the elderly, with more complex chronic complications as well as poor clinical results. The consumption of most suspected nephrotoxic drugs (including aminoglycosides, glycopeptide antibiotics, antifungal agents, beta lactam antibiotics, diuretic, ferralia, adrenergic receptor agonists and drugs for cardiac insufficiency therapy) still rose and was related to worse prognosis post- CA-AKI.

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