Kotloff KL, et al. - Among infants and children residing in low-income and middle-income countries, researchers analyzed the incidence, aetiology, and adverse clinical consequences of less severe diarrhoeal episodes. According to this one-year, multisite, age-stratified, matched case-control study following on to the GEMS study, participant inclusion with less-severe diarrhoea (LSD) significantly expands the population of children experiencing adverse clinical and nutritional outcomes from acute diarrhoeal diseases. Because moderate-to-severe diarrhoea and LSD have similar aetiologies, rotavirus-based interventions, Shigella spp, enterotoxigenic E coli producing heat-stable toxin, and Cryptosporidium spp could significantly reduce the burden of diarrhoeal disease and its associated nutritional failure.