Peterse EFP, et al. - In this microsimulation analysis to help update the American Cancer Society CRC screening guideline, researchers re-assessed the optimal screening strategies considering the increase in colorectal cancer (CRC) diagnosed in young adults by adjusting the MISCAN-Colon model (Microsimulation Screening Analysis-Colon). For different strategies, life-years gained (LYG; benefit), the number of colonoscopies (COL; burden) and the ratios of incremental burden to benefit (efficiency ratio [ER] = ΔCOL/ΔLYG) was used. They used ER thresholds in accordance with the previously accepted ER of 39 to determine the model-recommended strategies, as was done for the US Preventive Services Task Force. Based on the findings, they concluded that screening may be offered earlier than has previously been recommended in the light of the increase in CRC incidence among young adults.