Li L, et al. - In this study based on marginal structural Cox models, a cohort of all individuals (5,047 incident SLE and 25,235 non-SLE people) with incident SLE who received healthcare between January 1, 1997, and March 31, 2015, was recruited in order to estimate the independent risk of hip fractures in people with newly diagnosed SLE in comparison with the general population, accounting for baseline and time-varying confounders. A total of 73 and 272 hip fractures during 78,915 and 395,427 person-years, respectively, were obtained. The HR following additional adjustment for time-dependent covariates persisted to be important. It was concluded that in comparison with non-SLE individuals, people with newly diagnosed SLE have a 62% heightened risk of hip fractures. Moreover, this conclusion has implications for the prevention of osteoporosis in SLE individuals which may result in hip fractures.