Qu Y, Liu J, Guo ZN, et al. - Researchers undertook this self-controlled interventional study to determine if remote ischaemic conditioning (RIC) can regulate heart rare variability (HRV) in humans. Participants were 50 healthy adults, in whom, serial beat-to-beat monitoring was conducted at the same seven time points (7, 9, and 11 AM; 2, 5, and 8 PM; and 8 AM on the next day) with or without RIC. The RIC protocol comprised 4×5-minute inflation/deflation in one arm and one thigh cuff at 200 mmHg pressure from 7:20 to 8 AM. According to the findings, HRV increment and sympathetic inhibition caused by RIC seemed on the early as well as delayed protective window of RIC, which may be suggestive of some of the underlying mechanisms whereby RIC may provide protection.