Nocera L, Wenzel M, Ruvolo CC, et al. - This study’s findings demonstrate that race/ethnicity predisposes to differences in clinical, as well as in pathological characteristics in intermediate-risk prostate cancer (IR PCa) patients. The results showed that Hispanics/Latinos are at higher and African-Americans are at lower risk of upstaging and/or upgrading, even after full statistical adjustment.

• The study enrolled a total of 20,391 IR PCa patients, 15,050 (73.8%) were Caucasian, 2,857 (14.0%) African-American, 1,632 (8.0%) Hispanic/Latino and 852 (4.2%) Asian.

• The highest age (64 years), highest PSA (6.8 ng/ml), and the highest rate of GGG3 (31.9%) were reported in Asian patients.

• It was shown that African-Americans demonstrated the highest percentage of positive cores at biopsy (41.7%) and the highest proportion of NCCN unfavorable risk group membership (54.6%).

• Furthermore, Caucasians demonstrated the highest proportion of cT2 stage (35.6%).

• The findings demonstrated that in univariable analyses, Hispanic/Latinos demonstrated the highest rates of upstaging/upgrading among all race/ethnicities, in both favorable and unfavorable groups, followed by Asians, Caucasians, and African-Americans in that order.

• According to the findings, Hispanic/Latino race/ethnicity represented an independent predictor of higher upstaging and/or upgrading in favorable IR PCa (odds ratio [OR] 1.27, p < 0.01) in multivariable analyses, while African-American race/ethnicity represented an independent predictor of lower upstaging and/or upgrading in unfavorable IR PCa (OR 0.79, p < 0.001).