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The impact of preeclampsia definitions on the identification of adverse outcome risk in hypertensive pregnancy ‐ Analyses from the CHIPS trial (Control of Hypertension in Pregnancy Study)

BJOG: An International Journal of Obstetrics and Gynaecology Nov 27, 2020

Magee LA, Singer J, Lee T, et al. - Researchers here examined how preeclampsia definition associates with pregnancy outcome via conducting secondary analysis of CHIPS trial data. Participants were 987 women with non‐severe non‐proteinuric pregnancy hypertension. Among 979/987 women with informative data, progression to pre‐eclampsia defined restrictively by new proteinuria was observed in 280 women (28.6%), and progression to preeclampsia defined broadly as proteinuria or one/more maternal symptoms, signs, or abnormal laboratory tests, was reported in 471 women (48.1%). Relative to restrictive definition, the broad definition had significantly higher sensitivities, lower specificities, and similar or higher DOR and ‘true’ to ‘false’ positives ratios. Improvement in sensitivity was noted with adding available fetoplacental manifestations (stillbirth or birthweight <10th centile) to the broad preeclampsia definition.

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