Armstrong MJ, Rastgardani T, Gagliardi AR, et al. - Researchers interviewed persons with Parkinson and carepartners, separately, using a semi-structured questionnaire, in order to ascertain the influence of off periods. Participants were 20 persons with Parkinson and their carepartners (total n = 40). Persons with Parkinson described off periods to be related with impairments in level of independence (eg relating to employment, mobility, activities of daily living and medication timing), socialization, leisure activities, driving, physical function, and psychological experiences. Carepartners reported influence of off period on their own independence, socialization, leisure, and psychological experiences. Based on findings, they emphasize clinicians to determine the daily impact of off periods on both persons with Parkinson and carepartners at clinical visits to inform treatment decisions and counseling. Incorporation of measures of off period impact into clinical trials targeting fluctuations is recommended to fully understand the effects of interventions for fluctuations.