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The impact of hip and knee osteoarthritis on the subsequent risk of incident diabetes: A population-based cohort study

Diabetologia - Clinical and Experimental Diabetes and Metabolism Sep 29, 2018

Kendzerska T, et al. – Researchers assessed the relationship between hip/knee osteoarthritis (OA) and incident diabetes in 16,362 adults aged ≥55 years in this population-based cohort study. Walking limitation was defined as self-reported difficulty standing/walking in the last 3 months. The researchers used Cox regressions to evaluate the relationship of baseline hip/knee OA with incident diabetes, controlling for age, sex, body mass index, income, hypertension history, cardiovascular disease, and primary care exposure. They also tested whether the observed effect was mediated through walking limitation. Of those included in the study, approximately 10% (n=1,637) met inclusion criteria for hip OA, 15% (n=2,431) for knee OA, and 24% (n=3,908) for walking limitation. Controlling for confounders, the researchers observed a significant relationship between the number of hip/knee joints with OA and incident diabetes. Findings suggested that diabetes risk could be reduced via increasing attention to OA and OA-related functional limitations.

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