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The impact of frailty on posttraumatic outcomes in older trauma patients: A systematic review and meta-analysis

The Journal of Trauma and Acute Care Surgery Apr 03, 2020

Zhao F, et al. - Via performing a systematic review and meta-analysis, researchers sought to determine the predictive value of frailty for posttraumatic outcomes including mortality, adverse discharge, complications, and readmission in trauma patients. They  systematically searched articles in PubMed, Embase, and Web of Science databases from January 1, 1990, to October 31, 2019. Inclusion of articles in McDonald et al.'s study (J Trauma Acute Care Surg. 2016;80(5):824-834) and Cubitt et al.'s study (Injury 2019;50(11):1795-1808) was performed for studies examining the association between frailty and outcomes in trauma patients. Among 11,313 retrieved entries, they included 13 studies (seven prospective and six retrospective cohort studies) involving 50,348 patients in the meta-analysis. Findings suggest a significant predictive value of frailty for greater than 30-day mortality, in-hospital and 30-day mortality, postoperative complications, Clavien-Dindo IV complications, adverse discharge, and readmission in elderly trauma patients. As per subgroup analysis, prospective studies established a greater association between frailty and postoperative complications.

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