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The impact of fertility preservation on the timing of breast cancer treatment, recurrence, and survival

Cancer Jun 29, 2021

Greer AC, Lanes A, Poorvu PD, et al. - By performing this retrospective cohort study, researchers sought to determine the influence of fertility preservation (FP) on breast cancer results. Participants were 272 females aged 20 to 45 years with newly diagnosed stage 0 to III breast cancer who had an FP consultation between 2005 and 2017. Of these, 123 (45.2%) had FP (fertility preservation–positive [FP+]) and the rest 149 did not receive FP (fertility preservation–negative [FP–]). Longer times to first treatment and neoadjuvant chemotherapy and from surgery to adjuvant chemotherapy were observed in females who had FP. Both groups showed comparable adjusted 3- and 5-year invasive disease–free survival (IDFS) rates. Overall survival (OS) did not differ between the 2 groups. Findings revealed that time to treatment was delayed by a small amount because of undergoing FP after a breast cancer diagnosis, however, such delay did not result in inferior IDFS or OS.

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