The impact of ethnicity on the clinical presentations of spinocerebellar ataxia type 3
Parkinsonism & Related Disorders Feb 25, 2020
Gan SR, Figueroa KP, Xu HL, et al. - Given the well-established effect of ethnicity on the disease phenotypes of a variety of sporadic neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis, researchers here sought to determine how the ethnicity could contribute to the clinical symptoms and disease progressions in monogenetic disorders, such as spinocerebellar ataxia type 3 (SCA3). Using multivariable linear and logistical regression models, they assessed 257 molecularly-confirmed SCA3 patients (66 Caucasians, 43 African Americans, and 148 Asians [composed of 131 Chinese and 17 Asian Americans]). Outcomes revealed an important role of ethnicity in clinical presentations of SCA3. Relative to Caucasians and African Americans, Asian SCA3 patients have a significantly older age of disease onset. They observed more severe ataxia among African American SCA3 patients. Depression was identified more commonly among Caucasian SCA3 patients. The distinct impact of ethnicity on the motor and non-motor symptoms of SCA3 was evident.
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