Wall BT, Cruz AM, Otten B, et al. - This study was undertaken to determine if anabolic resistance was correlated with reduced postprandial amino acid uptake or exacerbated by excess lipid availability. For this analysis, 20 men underwent 7 days of forearm immobilization while consuming a eucaloric (CON; n = 11) or high-fat overfeeding (HFD; n = 9; 50% excess energy as fat) diet (parallel design) within the Nutritional Physiology Research Unit. In either group, immobilization did not affect forearm muscle cross sectional area, but appeared to minimize postabsorptive phenylalanine and leucine net balances equivalently in CON and HFD. According to findings, disuse impairs a protein-rich meal's ability to promote positive muscle amino acid balance, which is exacerbated by dietary lipid oversupply. In addition, disuse decreased postprandial forearm amino acid uptake, but this is not exacerbated under high-fat conditions.