Daugaard CL, Henriksen M, Riis RGC, et al. - Researchers performed this study with people with overweight and knee osteoarthritis (OA), to determine how weight loss can influence inflammation in these individuals, using both static- and dynamic contrast-enhanced (DCE)-MRI. They also evaluated the link of these changes to pain. The participants having overweight (BMI > 27) and knee OA were analyzed prior to and following a > 5% weight loss over 8 weeks. Complete data were provided by 117 participants. Mean weight loss was 12 kg. Improvement in KOOS (knee injury and osteoarthritis outcome score) pain by 13 points was evident at follow-up. There was no link between change in inflammation and weight loss in static MRI. No MRI variables showed correlation with the alteration in KOOS pain. Overall, no significant alteration in inflammation was brought about by weight loss in people with overweight and OA. The significant clinical beneficial impact of weight loss on knee pain in this population appeared uncoupled to alterations in imaging markers of synovitis.