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The efficacy and safety of peripheral intravenous parenteral nutrition vs 10% glucose in preterm infants born 30 to 33 weeks’ gestation: A randomised controlled trial

BMC Pediatrics Aug 20, 2020

Suganuma H, Bonney D, Andersen CC, et al. - Researchers conducted this parallel group, single centre, superiority, non-blinded, randomised controlled trial to compare a low osmolarity peripheral intravenous parenteral nutrition (P-PN) solution with peripheral intravenous 10% glucose on growth rate in preterm infants born 30 to 33 weeks’ gestation. Ninety-two (P-PN 42, control 50) infants born 30+ 0 to 33+ 6 weeks’ gestation, were randomised within 24 h of age, to obtain either P-PN (8% glucose, 30 g/L amino acids, 500 IU/L heparin and SMOFlipid) or a control of peripheral intravenous 10% glucose. Compared with peripheral intravenous 10% glucose, P-PN improves the rate of weight gain to discharge home in preterm infants born 30 to 33 weeks gestation. No significant differences were observed in any other clinical or biochemical outcomes.

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