Sheen YS, Huang HY, Liao YH., et al. - Dehydration and degradation of the structural components in the dermis are features of aging skin. Researchers examined the efficacy and safety of a serum containing hesperetin 0.1% and sodium cyclic lysophosphatidic acid (NcPA) 0.1% for photoaged skin via a trial consisting of a 12‐week topical application of the test product twice daily with 35 female individuals. At week 12, they identified a significant improvement of stratum corneum hydration and skin elasticity relative to baseline. Outcomes overall suggest significant antiaging effects of skin care products containing hesperetin and NcPA on skin hydration and elasticity. Significantly improved scores of hyaluronic acid levels and elastic fiber structure were seen in the skin biopsy. After 12 weeks, patient satisfaction with the test product was 94.3%.