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The effects of vitamin E supplementation on malondialdehyde as a biomarker of oxidative stress in haemodialysis patients: A systematic review and meta- analysis

BMC Nephrology Apr 15, 2021

Bergin P, Leggett A, Cardwell CR, et al. - Researchers conducted a systematic review and meta-analysis to investigate how vitamin E (VE) supplementation could impact malondialdehyde (MDA) levels in haemodialysis (HD) patients. Also, it was assessed for its potential as a therapeutic modality to decrease cardiovascular disease risk as well as all-cause mortality in HD patients. Relevant studies were identified from MEDLINE and EMBASE. The standardised mean difference of MDA concentrations from 18 comparisons was identified to be significantly lower in HD patients after VE supplementation. Overall, VE use in HD patients for decreasing the effects of oxidative stress, is supported by the findings.

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