Pask S, et al. - Following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols, researchers conducted a systematic literature review to identify, appraise, and synthesize evidence on the effect of opioids on cognition in older adults with cancer/chronic noncancer pain. Further, they sought for screening tools/neuropsychological assessments employed to recognize opioid-induced cognitive impairment. They included 10 records in this work. One screening tool was used in five studies, and a range of neuropsychological assessments was used in five studies; assessing 14 cognitive domains. Studies with higher mean opioid doses (120–190.7mg oral morphine equivalent daily dose) showed both improvements and impairments to cognition. In particular, worsening of attention, language, orientation, psychomotor function, and verbal working/delayed episodic memory were reported. In clinical practice, a brief screening tool assessing these domains may aid in detecting worsening cognition in older adults with chronic pain using opioids.