Doyle MD, Hastings G, Dontsi M, et al. - Researchers aimed at ascertaining the effects of timing between endovascular intervention and minor lower-extremity amputations and its influence on wound healing and limb loss within 1 year. Further, they investigated how restoring in-line flow affects healing rates. They assessed a total of 310 patients who underwent endovascular intervention and a minor lower-extremity amputation within 90 days. Statistically significant difference was noted between patients with optimal healing to delayed healing and amputation ≥ 30 days after endovascular intervention. Following factors were identified as significant for failing to heal: absence of in-line flow, male gender and diabetes mellitus. Also, they noted a failure to heal in correlation with presence of infection and wound dehiscence. End-stage renal disease trended toward significance for failing to heal. Findings suggest that in the absence of infection, improved healing may be achieved with performing minor lower-extremity amputations 15 to 60 days after endovascular intervention.