Fathi M, Massoudi N, Nooraee N, et al. - In view of the observation that the residual depressant effects of anesthetics, sedatives and opioids may often be responsible for postoperative respiratory failure and airway obstruction after bariatric surgery, researchers here examined how doxapram affects the outcomes of general anesthesia following bariatric surgical procedures in the morbidly obese. They conducted a single-blind randomized controlled trial with two parallel arms at a tertiary care teaching hospital, Tehran, Iran, from 2017 to 2018. They included 100 patients (69 women) with at least class two obesity in two groups of equal sizes; bariatric surgery was performed on these patients. Both groups were provided general anesthesia. A single dose of doxapram 1 mg kg−1 ideal body weight was provided to the intervention group, immediately following reversal of neuromuscular blockade and after discontinuation of all anesthetics. Outcomes revealed correlation of providing doxapram postoperatively with improvement in peak expiratory flow rate, and reduction in respiratory complications of anesthesia during recovery in the morbidly obese undergoing bariatric surgery. Young ASA physical status classes 1 to 2 morbidly obese patients well tolerated doxapram; however, they suggest the anesthesiologist to cautiously evaluate the vital signs for at least half an hour after the administration of doxapram.