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The effects of a combined intervention (DHA supplementation and home-based dietary counseling) on metabolic control in obese and overweight pregnant women: The MIGHT study

American Journal of Obstetrics and Gynecology Nov 05, 2020

Garmendia ML, Casanello P, Flores M, et al. - In this randomized controlled trial, researchers sought to assess the impact of docosahexaenoic acid (DHA) supplementation among obese and overweight pregnant women (independently or combined with a dietary counseling intervention) on metabolic control in mothers and their offspring. The criteria for inclusion were: < 15 weeks of gestation; body mass index > 25 kg/m2 at the first prenatal visit; singleton pregnancy; and 18 years of age or older. Recruited women (n = 1,002) were randomly assigned to one of the four parallel groups: Group 1: dietary counseling + 800 mg/day of DHA (n = 250); Group 2: routine counseling + 800 mg/day DHA (n = 252); Group 3: dietary counseling + 200 mg/day DHA (n = 249); and Group 4: routine counseling + 200 mg/day DHA (n = 251) considered to be the reference group. Data reported that the overall incidence of GDM was 20.2% (Group 1: 21.0%, Group 2: 20.1%, Group 3: 18.9%, and Group 4: 20.9%). This combined intervention did not minimise the risk of gestational diabetes in mothers or macrosomia and insulin resistance in neonates for women who were overweight or obese at the beginning of pregnancy.

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