Omara AF, et al. - Researchers examined how oral pregabalin affects the duration and quality of postoperative analgesia in spinal anesthesia. Sixty adult patients, who presented for internal fixation of femoral fracture under spinal anesthesia, were randomly assigned to a placebo group or a pregabalin group receiving 150 mg pregabalin capsules 1 hr before the surgery. In the pregabalin group, they observed significantly prolonged time to two-segment regression of sensory block (reaching 86.67±17.88 mins), significantly prolonged time required to regression of spinal block to L2 (reaching 155.33± 34.71 mins), and significantly prolonged duration of motor block (reaching 138 ± 23.5 mins) were observed with no effect on the onset of sensory or motor block. Pregabalin led to a significant reduction in the VAS score 4 hrs, 6 hrs, and 12 hrs postoperatively, prolonged the duration of postoperative analgesia, reaching 392.00±47.23 mins, and reduced morphine consumption to 7.67±3.65 mg. In addition, it led to an improvement in the quality of sleep on the first night after surgery.