Kurtulmus-Yilmaz S, et al. - This study was designed to assess the impact of different surface treatments on mechanical and optical properties of lithium disilicate ceramic (IPS e.max CAD), 2 resin nanoceramics (Lava Ultimate, GC Cerasmart), and polymer-infiltrated ceramic network material (Vita Enamic). Findings demonstrated that the flexural strength and optical properties of CAD/CAM restorative materials were influenced by surface treatments. Furthermore, data indicated that Er,Cr:YSGG laser irradiation with 2 W energy level may be an alternative surface treatment method for CAD/CAM materials.