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The effect of successful trabeculectomy on the ocular surface and tear proteomics—A prospective cohort study with 1‐year follow‐up

Acta Ophthalmologica Mar 18, 2021

Vaajanen A, Nättinen J, Aapola U, et al. - Researchers conducted the study for reporting changes in the ocular surface and tear proteomics after discontinuation of chronic glaucoma medication. Patients requiring trabeculectomy were selected from the glaucoma clinic of Tampere University Hospital, Finland. Fifty‐seven patients with a previous history of anti‐glaucomatous eye drops and having undergone a successful trabeculectomy were involved in this report. Clinical signs and proteomics results both indicated that trabeculectomy and the subsequent cessation of topical glaucoma medication were extremely beneficial to the ocular surface. During the 1‐year follow‐up, the conjunctiva improved, while pro-inflammatory protein levels decreased and lipid transport-associated functions increased.

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