Lipton RB, Seng EK, Chu MK, et al. - In people with episodic migraine or chronic migraine, researchers explored the impacts of depression and anxiety on headache‐related disability. Sociodemographic and headache characteristics and headache‐related disability (Migraine Disability Assessment Scale) were evaluated in this cross‐sectional analysis of data from the longitudinal, internet‐based Chronic Migraine Epidemiology and Outcomes Study evaluated. They included 16,788 participants who were mainly female (74.4% [12,494/16,788]) and white (84.0% [14,044/16,788]), with a mean age of 41 years. Results determined that depression alone was linked to a 56% greater risk of moderate/severe migraine‐related disability and anxiety alone was linked to a 39% greater risk of moderate/severe migraine‐related disability, after controlling for sociodemographic and headache features. An even higher risk of moderate/severe disability was seen if both were present (79%). Depression and anxiety together are more closely related to disability than either comorbidity alone. Any disability associated with headache in people with migraine may be improved by focusing on treating depression and anxiety, as well as migraine itself.