Grosso MJ, et al. - In this study, researchers intended to ascertain the role of preoperative anemia status on 30-day complications following total hip arthroplasty. They identified all patients who underwent primary total hip arthroplasty (THA) using the National Surgical Quality Improvement Program registry between 2006 and 2016. They divided individuals into 3 cohorts based on preoperative hematocrit levels (Normal > 36% [N=166,538], Mild Anemia 27%-36% [N=13,214], Severe Anemia < 27% [N=541]). Using bivariate and multivariate analyses, they compared differences in 30-day postoperative medical complications and readmission rates. This multivariate logistic regression analysis distinguished mild anemia compared to normal hematocrit as a significant risk factor for total complications, mortality, renal complications, respiratory complications, sepsis, wound infection, and urinary tract infection. They indicated that preoperative anemia is a significant risk for perioperative complications following primary THA. In THA, despite mild anemia can lead to significantly elevated risks of mortality, medical complications, and unplanned hospital readmissions in THA. This study further substantiates the need for screening and preoperative intervention for individuals in this at-risk group.