Huang SHS, et al. - Analyzing serum samples of the Frequent Hemodialysis Network (FHN) Daily and Nocturnal Trials, researchers investigated if switching to more frequent hemodialysis would influence lowering of predialysis cystatin C (CysC) and beta-2 microglobulin (β2-M) serum concentrations. They determined predialysis CysC and β2-M serum levels. At baseline (while on conventional thrice weekly dialysis), and after 12-months of study (on more frequent dialysis), the differences between predialysis concentrations at both these time points were compared separately by trial (Nocturnal, Daily). β2-M vs CysC could be a better biomarker of dialysis dose. Attenuation in the level of potentially toxic long-lived proteins of the size of β-2M with more intensive dialysis was considered as its one potential long-term benefit.