Lavery LA, Killeen AL, Farrar D, et al. - Researchers sought to determine the effect of continuous diffusion of oxygen therapy (CDO) on cytokines, perfusion, and bacterial load in patients with diabetic foot ulcers. From 23 evaluated patients, they obtained tissue biopsies at each visit to evaluate cytokines and quantitative bacterial cultures. Hyperspectral imaging and transcutaneous oxygen were used to measure perfusion. An increase was noted from baseline to week 1 in TGF‐β, TNF‐α, VEGF, PDGF, and IGF‐1; baseline to week 2 in TGF‐β, VEGF, and IL‐6; and baseline to week 3 with TGF‐β and IL‐6. Transcutaneous oxygen increased significantly after 1 week of therapy on both medial and lateral foot. At least a 50% wound area reduction was observed in 53% of the patients (healers). At baseline, healers and nonhealers showed no differences in cytokines. Relative to nonhealers, healers showed a significant raise in tissue cytokines after the application of CDO. However, nonhealers had an increase in CXCL8 after 1 week of treatment and IL‐6 after 3 weeks of treatment.