Kent I, et al. - In this prospective, single site, observational study, researchers investigated the impact of routine screening colonoscopy, an endoscopic examination of the bowel, performed under sedation on the intraocular pressure (IOP) in healthy people. Healthy adults undergoing routine colonoscopy performed under sedation including propofol, fentanyl, and midazolam have been selected. Participants in the study were 23 Caucasians [mean age was 60.4 ± 10.4 years (range 36–74)]. Colonoscopy under sedation was performed and completed in 22 individuals. Findings revealed that the mean IOP baseline was 19.9 ± 4.7 mmHg, 15.8 ± 4.8 mmHg immediately after sedation, 13.5 ± 2.3 mmHg when the colonoscope entered the cecum, 15.4 ± 5.0 mmHg 5 min after the beginning of colonoscopy, and 16.5 ± 5.5 mmHg in the rectum. During the procedure, the IOP reduction was statistically significant. Overall, the authors concluded that routine colonoscopy with propofol, fentanyl, and midazolam performed under sedation does not increase IOP in healthy adults.