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The effect of clomiphene citrate on endometrial thickness, ovulation, pregnancy and live birth in anovulatory women: A systematic review and meta-analysis

Ultrasound in Obstetrics & Gynecology Evidence based | Nov 08, 2017

Gadalla MA, et al. - Authors aimed at comparing the impact of clomiphene citrate (CC) vs other drug regimens on mid-cycle endometrial thickness (EMT), ovulation, pregnancy and live birth rates in women with WHO group II ovulatory disorders. As per observation, ovulation induction with CC might result in thinner EMT than other ovulation induction regimens in women with WHO group II ovulatory disorders. Further studies seemed required to assess whether the thinner EMT caused the lower pregnancy and live birth rates. Letrozole seemed beneficial for these women. However, they suggested to practice caution while considering the findings as the quality of evidence was very low.
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