The effect of atrial fibrillation intervention on nocturnal respiratory events in elderly patients with persistent AF
The Clinical Respiratory Journal Feb 28, 2019
Eysenck W, et al. - In this study conducted with 67 patients (aged 66 to 86, 53% male) with persistent atrial fibrillation (AF), researchers assessed 6 month home sleep testing data following randomization of patients (1:1:1) to AF intervention including direct current cardioversion (DCCV) (n=22), permanent pacemaker (PPM) + atrioventricular node ablation (AVNA) + DCCV (n=22) or AF ablation (n=23). Using the Watch-PAT200 (WP), baseline and 6-month multichannel home sleep tests were recorded. A 60% prevalence of moderate-to-severe sleep-disordered breathing (SDB) (apnea-hypopnea index (AHI) ≥15/h) was reported. A remarkable attenuation in AHI was evident in association with restoration of sinus rhythm, and the related long-term recovery of hemodynamics. This implicates reversal of fluid shift from the lower limbs to the neck region, a key mechanism in the pathogenesis of SDB.
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