Lin C, Ly M, Karim HT, et al. - Given the initiation of pathological processes contributing to Alzheimer’s disease decades prior to the onset of clinical symptoms and that cognitive changes vary significantly in the presence of pathology, researchers examined if functional connectivity may be a marker of compensation to amyloid. Sixty four cognitively normal older adults were recruited and were made to undergo neuropsychological testing and biannual MRI, amyloid imaging with Pittsburgh compound B (PiB)-PET, and glucose metabolism (FDG)-PET imaging for up to 6 years. The analysis revealed a significant increase in the resting-state functional connectivity of older participants over 2 years in the left middle frontal gyrus (MFG) within the memory encoding network (MEN). A diminished increase in functional connectivity was observed among participants with greater amyloid deposition vs those with lower amyloid deposition. Results imply that the presence of early alterations of network connectivity could be identified before the overt cognitive decline, which may serve as a mechanism for maintaining homeostasis in the context of age-related changes, amyloid deposition, or other neurodegenerative changes.