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The effect of a screening and treatment program for the prevention of fractures in older women: A randomized pragmatic trial

Journal of Bone and Mineral Research Jun 28, 2019

Merlijn T, et al. - Researchers assessed whether screening for fracture risk and subsequent treatment in primary care decreases fractures in comparison to usual care. For this investigation, 11,032 women (aged 65-90 years) with ≥ 1 clinical risk factor for fractures were individually randomized to screening (n=5,575) or usual care (n=5,457). Post hoc explorative finding proposed that, after a recent fracture, screening might be most effective. Non-participation and medication non-adherence in the screening group could have affected the outcomes of this research. Overall, this research did not provide enough clues for fracture prevention screening to be considered. However, due to the relatively small number of women with a treatment indication in the intervention group, the authors cannot exclude their clinical relevance for reducing (major) osteoporotic fractures and hip fractures.

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