Bassiouni M, Kang G, Olze H, et al. - Researchers conducted the study for examining the various underlying pathologies of cervical lymphadenopathy as evaluated by the diagnostic yield of excisional lymph node biopsies of the neck in a tertiary adult practice. Between January 2017 and December 2019, 158 adult patients who received an excisional biopsy for suspected cervical lymphadenopathy at a tertiary referral head and neck service were studied retrospectively. Unspecific and/or reactive lymphadenitis was the most common underlying pathology in 44.5% of cases, followed by malignant disease in 38.6% of cases. Data reported that the overall surgical complication rate was 2.5%. The current study's findings are indicative of the wide range of etiologies that cause cervical lymphadenopathy. Given the increasing incidence of malignant diseases in recent decades, the findings should raise awareness among physicians about the importance of lymph node biopsy in excluding malignancy in persistent cervical lymphadenopathy, particularly in older adults. The findings highlight the importance of neck excisional lymph node biopsy as a useful diagnostic tool in adult patients with peripheral lymphadenopathy.