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The density of endometrial glandular openings: A novel variable to predict the live birth rate in patients with intrauterine adhesions following hysteroscopic adhesiolysis

Human Reproduction Jan 28, 2021

Zhao X, Gao B, Yang X, et al. - Researchers examined if the density of endometrial glandular openings (DEGO) is a reliable and simple new variable for the prediction of live birth after hysteroscopic adhesiolysis. They enrolled a test cohort of 457 patients with intrauterine adhesions (IUAs) who underwent hysteroscopic adhesiolysis and had satisfactory follow-up hysteroscopy videos. Validation was performed in a cohort of 285 IUA patients. The follow-up hysteroscopy videos were tested by an automated counting software to determine the DEGO grade of all the 742 patients with IUAs after hysteroscopic adhesiolysis. In addition, the American Fertility Society (AFS) score was calculated for each patient at the same follow-up hysteroscopy. The test cohort had 231 patients who had a live birth, but failure was reported in 226 patients. The validation cohort had 117 patients who had a live birth, while there were 168 who did not. Findings suggest superiority of the DEGO grade at follow-up hysteroscopy over AFS score in predicting the live birth rate after hysteroscopic adhesiolysis for patients with IUAs.

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