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The current practice of opioid for cancer dyspnea: The result from the nationwide survey of Japanese palliative care physicians

Journal of Pain and Symptom Management Aug 31, 2019

Yamaguchi T, et al. - Performing a nationwide mail-questionnaire survey among 536 Japanese certified palliative care physicians, the physician-reported practice of opioid for cancer dyspnea was investigated among these physicians. Responders were 192 physicians (response rate, 71.6%). They reported “immediate-release morphine as needed” in opioid-naïve patients as the major (58.3%) practice of initiating morphine, and the mean % increase by 29.4% ± 11.3% of the baseline dose when morphine titration is considered for cancer dyspnea. Although for low-to-moderate–dose regular oxycodone cases, “titrate baseline oxycodone” was the most frequent (42.3%) practice, “stepwise switch to morphine” (30.0%) and “add morphine on baseline oxycodone” (27.1%) were the more frequent practices for high-dose regular oxycodone cases. For regular transdermal fentanyl cases, “add morphine on baseline fentanyl” was the most frequent practice regardless of the baseline dose. In renal insufficiency cases, the most frequent choice was oxycodone, regardless of its degree.
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