Kurose N, et al. - Experts pursued a comparison of the nodal cases of idiopathic multicentric Castleman disease (MCD) with and without thrombocytopenia, anasarca, fever, renal failure or reticulin fibrosis, and organomegaly (TAFRO syndrome) syndrome. The hyperV-type illustrated severe atrophic lymphoid follicles (LF) and interfollicular vascular proliferation. It was determined that the serum IL-6 levels in idiopathic MCD (iMCD) with TAFRO were considerably higher among the mixed type cases than those in iMCD without TAFRO. In contrast with iMCD without TAFRO, the numbers of immunoglobulin G4 (IgG4)-positive and CD38-positive plasma cells appeared to be notably decreased in iMCD with TAFRO.